Technologies & Assets

#CEITEC MU-004 RNAutriX begin with screening services, generating a proprietary dataset of RNA–small molecule interactions. Develops tools for drug design, scaffold generation, and off-target prediction. In the long term, RNAutrix will develop its own RNA-targeted therapeutics and custom HTS instrumentation, contributing unique RNA–ligand insights to accelerate the future of RNA-targeted drug discovery and development....

#CEITEC MU-003 Method to increase plant resistance to abiotic stress, particularly drought and soil salinity, by upregulating DIR13 gene expression. Abiotic stresses like drought and salinity significantly impact crop yields. Climate change exacerbates these challenges, necessitating innovative solutions. This invention focuses on enhancing plant resilience through genetic means. ...

#CEITEC MU-002 A method for designing unique peptides that can selectively target and Disrupt cellular membranes of pathogens without damaging human cells. Increasing incidence of antibiotic resistance in bacteria, along with a steady decline in the Discovery of new antibiotics, presents a global health challenge. There is a need for the discovery of...

#CEITEC MU-001 The researchers from Masaryk University developed a DNA-aptamer-based inhibitor that, in contrast to FGFR TKIs, inhibits FGFR1 but not the other existing FGFR variants (FGFR2, FGFR3, and FGFR4). In contrast to the current generation of TKIs, which targets the intracellular (kinase) domain of FGFR, the aptamer targets its extracellular domain; it significantly...

#LIOS-004 MitoCLue is a novel fluorescent probe that enables 3 complementary cardiolipin (CL) assays – binding affinity measurement, CL quantitative analysis, and CL imaging. Designed for both mitochondrial research and drug safety profiling, MitoCLue supports drug discovery with high-throughput, reproducible and biologically relevant results. Cardiolipin (CL) is a key phospholipid responsible for mitochondrial...

#LIOS-003 This iodine(III) reagent is of interest to the medicinal chemistry and synthetic organic chemistry communities. It is an efficient and versatile tool for generating new fluorine-containing compounds for drug development. Specifically, photoredox-catalyzed radical fluoromethylation applications of alkenes[1] and heterocycles[2]. Organofluorine compounds are of enormous importance in medicinal chemistry, as the fluorine atom...

#LIOS-002 Preclinical pharmacokinetic and safety studies in rodents assess ADME, bioavailability, and clearance to guide dosing. Using routes like oral, IV, or minipumps, and advanced analytics, the service identifies toxic effects, target organs, and supports safe, effective drug development. Pharmacokinetics (PK) help determine a compound’s bioavailability and clearance, guiding dosing strategies by tracking...

#LIOS-001 The TMLHE KO mouse (C57BL/6N) is a valuable model for studying lipid metabolism, mitochondrial dysfunction, and oxidative stress. With low acylcarnitines and reduced FAO, it enables cardiometabolic research, drug testing, metabolic reprogramming, and therapeutic screening. This conventional (constitutive) TMLHE KO model (C57BL/6N background) is useful for research and drug development for diseases...

#UT-001 Our new, patent protected, preeclampsia (PE) prognosis method relies on a panel of at least four biomarkers, which concentrations in maternal blood serum are simultaneously measured in a single test tube, and at least one clinical cofactor. With our method, it is now possible to predict the development of PE or the absence...

#UT-001 Our new method of selection of embryos suitable for uterine transfer and implantation relies on We have discovered specific RNA transcripts which expression level in endometrial cell lines (responder cells) are indicative of the embryo quality and allow to establish an implantation prognosis. In vitro fertilization (IVF), is the most common and...