Article list

#LIOS-004 SUMMARY MitoCLue is a novel fluorescent probe that enables 3 complementary cardiolipin (CL) assays – binding affinity measurement, CL quantitative analysis, and CL imaging. Designed for both mitochondrial research and drug safety profiling, MitoCLue supports drug discovery with high-throughput, reproducible and biologically relevant results. BACKGROUND Cardiolipin (CL) is a key phospholipid responsible for mitochondrial…

#LIOS-003 SUMMARY This iodine(III) reagent is of interest to the medicinal chemistry and synthetic organic chemistry communities. It is an efficient and versatile tool for generating new fluorine-containing compounds for drug development. Specifically, photoredox-catalyzed radical fluoromethylation applications of alkenes[1] and heterocycles[2]. BACKGROUND Organofluorine compounds are of enormous importance in medicinal chemistry, as the fluorine atom…

#LIOS-002 SUMMARY Preclinical pharmacokinetic and safety studies in rodents assess ADME, bioavailability, and clearance to guide dosing. Using routes like oral, IV, or minipumps, and advanced analytics, the service identifies toxic effects, target organs, and supports safe, effective drug development. BACKGROUND Pharmacokinetics (PK) help determine a compound’s bioavailability and clearance, guiding dosing strategies by tracking…

#LIOS-001 SUMMARY The TMLHE KO mouse (C57BL/6N) is a valuable model for studying lipid metabolism, mitochondrial dysfunction, and oxidative stress. With low acylcarnitines and reduced FAO, it enables cardiometabolic research, drug testing, metabolic reprogramming, and therapeutic screening. BACKGROUND This conventional (constitutive) TMLHE KO model (C57BL/6N background) is useful for research and drug development for diseases…